News About Chronic Cerebrospinal Venous Insufficiency Treatment in Multiple Sclerosis

Zivadinov_447x260The January 2014 issue of Vascular Disease Management includes an interview with Robert Zivadinov, MD, on the Prospective Randomized Endovascular Therapy in MS (PREMiSe) trial, which studied balloon angioplasty for the treatment of multiple sclerosis. In the interview, Dr. Zivadinov admits that he was surprised by the results, which he describes as follows:

“The primary endpoint of the study was safety at 24 hours and 1 month. There were really no serious adverse events—neither over the 6 month period nor now at the 12 month mark of the study. The other endpoint was the restoration of the blood flow, which was measured immediately postprocedure on catheter venography. One of the criteria was that blood flow should be restored at least by 50% after the procedure and that was achieved at 1 month, as measured by duplex; the restoration should have reached 75% of the flow improvement and there was no difference between the treated and not treated patients.”

Readers have shared conflicting opinions on this topic in the comments:

  • “These are very interesting results which I believe are totally consistent with my observations having followed over 200 MS patiently with CCSVI treated by venoplasty.”
  • “Venous obstruction itself does not cause the periventricular punching out of lesions seen in MS.”
  • “I totally disagree with Dr. Zivadinov, I think venous angioplasty is a highly effective treatment for CCSVI and MS.”
  • “In my opiniion premise study just didn’t had success with angioplasty and correcting the flow – that is the purpose of treatment.”

What are your thoughts? View reader comments and share your own at “Results of the PREMiSe Study on CCSVI in MS: An Interview With Robert Zivadinov, MD, PhD.”

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